Phoenix to San Diego is our second-most-run California route after LA. We do 4-6 a month, mostly retirees moving to coastal San Diego from Phoenix metro and tech workers relocating from Phoenix to San Diego biotech and defense employers.
The drive is I-8 west through Yuma and the Imperial Valley β about 355 miles, 5.5 hours straight. Easier than LA because no LA traffic to deal with. We typically do pickup Day 1, deliver Day 2 morning, no overnight stop required for most loads.
BBB A+